I'm currently reading about radiation hybrid mapping with a TSP (traveling salesman problem) application in order to find an ordering of the genetic markers (i'm a mathematics student) and was wondering about the usefulness of the procedure. If the end result determines the proximity of certain genetic markers then we can draw inferences about genes which are in close proximity to each other and genes which are separated with a larger distance. I'm wondering for certain set of genes if they are closely related distance wise then are the properties for the genes often related to each other? I believe there are also genes which are dependent upon having other genes in close proximity in order to function properly if I am not mistaken. Is this true?
I'm also curious as to what we may say if we have for instance two genes which are separated by large distance? May this be related to the fact that the farther away two genes are the more they act like they are unlinked?
Any help is appreciated.