0
$\begingroup$

Clonal deletion is a well-known mechanism of immune central tolerance. But individual lymphocytes or lymphocyte clones are subjected to apoptosis? If clones, then what is the reason to allow mitosis in auto-reactive cells? If lymphocytes, then why do we use the adjective? I mean are there several rounds of mitosis in a (potentially) harmful say B lymphocyte prior to negative selection step?

Improve this question
$\endgroup$

1 Answer 1

Reset to default
0
$\begingroup$

I think you misunderstood the definition of clone at this level. As clonal deletion is a central tolerance mechanism, of all the possible clones of B cells (a clone is a B cell with a particular arrangement of the BCR), those clones (not identical clones, but different clones each) that are self-reactive will undergo apoptosis. That means that self-reactive clones are deleted and they won't divide anymore.

Improve this answer
$\endgroup$
2
  • $\begingroup$ so, 1 clone = 1 B cell, any reference? $\endgroup$
    – abc
    Commented Apr 15, 2022 at 22:21
  • 1
    $\begingroup$ Your answer could be improved with additional supporting information. Please edit to add further details, such as citations or documentation, so that others can confirm that your answer is correct. You can find more information on how to write good answers in the help center. $\endgroup$
    – Community Bot
    Commented Apr 25, 2022 at 18:14

You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .