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It’s said that HIV selectively infects and kills CD4+ T cells, which disables the adaptive immunity because both CD8+ T cells and B cells need CD4+ T cells to activate them. However, once activated, memory B cells and CD8+ T cells can function independently of CD4+ T cell. Does that mean HIV+ people still retain immunity against previously encountered or vaccinated infections even at advanced disease stage?

Cited from:

As the affinity of surface Ig from memory B cells is increased, their requirements for reactivation are lower than for naïve B cells: memory B cells may thus be recalled by lower amounts of antigen and without CD4+ T cell help.

https://www.sciencedirect.com/science/article/pii/B9781416036111500064

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  • $\begingroup$ Welcome to SE Biology! It would be helpful to link to/cite sources for your information. $\endgroup$ Apr 15, 2022 at 19:38
  • $\begingroup$ Here: As the affinity of surface Ig from memory B cells is increased, their requirements for reactivation are lower than for naïve B cells: memory B cells may thus be recalled by lower amounts of antigen and without CD4+ T cell help. sciencedirect.com/science/article/pii/B9781416036111500064 $\endgroup$
    – 哲煜黄
    Apr 16, 2022 at 2:05
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    $\begingroup$ Please edit your link into your question - that way it is more likely to be read, and more likely to persist as comments can and do get deleted occasionally. $\endgroup$
    – bob1
    Apr 18, 2022 at 8:15

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