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I understand that gene-drives not only contain a genetic mutation brought about by CRISPR-CAS, but that rather they also contain the alleles necessary for CRISPR-cas to operate in descendants. Thus all heterozygous descendants will become homozygous for the mutation, as the engineered chromosome produces the CRISP-cas that will engineer the so-far non-engineered chromosome. As a result, the mutation will spread much more rapidly.

How this will influence evolution? What about, for instance, the impact on genetic drift, natural selection and sexual selection? Also, what will it do to speciation?

Thank you

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    $\begingroup$ This is certainly an interesting question, but I think it's possibly a bit too broad - drift and selection are really big topics! Perhaps you could focus it more to one specific kind of evolution you are interested in? $\endgroup$
    – user438383
    Apr 26, 2022 at 11:09

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