Uhh, please don't test in humans?
But conceptually, it should be about the same in humans.
That Bernard-Valnet PNAS paper presents evidence that these autoreactive CD8+ T-cells can trigger a narcolepsy-like phenotype in rodents, and it's widely accepted that a traumatic brain injury (TBI) can (probably pretty rarely) cause narcolepsy.
So, widespread death of orexinergic neurons probably can cause narcolepsy.
But it's not know whether that's a common cause.
An underlying cause (pathogenesis) could result in both idiopathic narcolepsy AND loss of orexinergic neurons.
In fact, Bernard-Valnet et al. say the same:
it is currently unknown whether autoantibodies precede or are the consequence of brain tissue destruction in narcolepsy
Though you might be able to give your human experimental subjects a long-term or permanent neurological disorder, it might not be the most useful model.