I am trying to understand to what extent human patients can regenerate liver mass after laprascopic segmentectomy: what part of liver will be regenerated and how fully.
My work with sources is not very good, but here is what I have found so far:
"Following surgical resection of the two anterior hepatic lobes of rodents accounting for ~68% of liver tissue, the remaining lobes undergo compensatory hyperplasia restoring the liver to its original presurgical mass" However, the article notes that:
"..PHx model doesn't apply to most common clinical scenarios.. patients who must regenerate liver mass after hepatic surgery often have cirrhosis, hepatic viral infection, steatosis.."
From this question (If the liver can regenerate why can alcohol abuse permanently damage it?) I gathered that only healthy hepatic tissue in liver can regenerate: the epithelial tissue. Cytotoxic drugs like alcohol lead to steatosis and cirrhosis. Cirrhosis is the substitution of epithelial tissue by connective tissue. This connective tissue not only can't regenerate: it doesn't perform hepatic functions.
Assuming that the patient has otherwise healthy liver tissue, if a laprascopic resection of liver segment Sg3 has been performed, what part of the liver will be regenerated?
Thank you in advance, and I would be happy to edit/update my question with more info.