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Can someone please provide a human friendly explanation.

to the following:

RNAp binds a defined site (a specific DNA sequence) at the promoter (Fig- ure 2.2a). The quality of this site specifies the transcription rate of the gene

what is the quality of the site?

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Quality is most likely related to how tightly RNAp binds to conserved sequences in the promoter, and that is related to how closely the actual sequences themselves are to RNAp's "most-preferred" sequences. The actual sequences can vary between genes, giving them different transcription rates.

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  • $\begingroup$ thank you for your explanation much appreciated $\endgroup$
    – yaya10
    Jun 7 at 21:44

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