Ellagic acid (a polyphenol) works as an antimicrobial compound. But what is its mechanism of action?

I found these 2 research papers related to this, however the mechanism of action is not clearly explained in either of them. Is there a paper that effectively explains the mechanism of action?

  • doi:10.3389/fmicb.2019.00829(in page 2, it is mentioned that the compounds are known to involve many sites of action at the cellular level, but why does it affect the site of action?)
  • doi:10.1002/chem.202000354 (In page 3, It has been postulated that ellagitannins inhibit the growth of microorganisms by sequestering metal ions critical for microbial growth, but direct bacterial targets remain unidentified. Is there a paper which explains why it inhibits growth more clearly?
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    $\begingroup$ What do you mean by mechanism of action? I would argue that those papers both present possible mechanisms of action related to cellular adhesion. Why does that not answer your question? $\endgroup$ Commented Jul 19, 2022 at 18:50
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    $\begingroup$ @MaximilianPress Indeed, in the first one, the entire second paragraph is entirely about this question; in the second one, it's a picture within the abstract - pretty rare to find a picture in an abstract, for sure, but certainly not hidden information. OP - can you clarify what is missing/where the gap is between these papers and what you want to know? $\endgroup$
    – Bryan Krause
    Commented Jul 19, 2022 at 18:57
  • $\begingroup$ Thank you for editing, but I don't think you've adequately addressed the above comments and thus have voted to leave closed. For example, as noted by Bryan the abstract of the second paper you link shows a clear mechanism that you seem to be ignoring. ——— Also note that questions on this site work best if they are narrowly focused — an example would be asking why biofilm disruption is important for antimicrobial activity, or better yet how biofilms contribute to infections in Streptococcus (including a summary with references of what you've learned about the question from your research). $\endgroup$
    – tyersome
    Commented Jul 30, 2022 at 0:18


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