The news item by Charles Piller just published in Science BLOTS ON A FIELD? A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer’s articles, threatening a reigning theory of the disease highlights the recent news and activity around a series of papers discussion Aβ*56, a specific, proposed type of toxic oligomer of amyloid beta or Aβ.
There are questions of image altering and of the veracity of Aβ*56 isolation and measurements, and expressions of concern have been recently added to online versions of a numnber of papers referring to it going back to the 2006 Nature paper A specific amyloid-β protein assembly in the brain impairs memory.
Several drugs developed for treatment of Alzheimers Disease have targeted Aβ.
I'm having difficulty understanding how far the implications of the recent concern reaches. Is it simply the correlation with the particular form Aβ*56 associating with Alzheimers, or is it the connection between any oligomer of Aβ? Does the recent concern over several papers about it call into question the association of Alzheimers Disease with any Amyloyd beta oligomer forms?