I would like to know about those transporters with alternating-access-type mechanism, that can only efficiently shuttle molecules in one direction but the other direction is severely kinetically inhibited. From this question I know that they exist, but Google searches are futile in finding examples. Wikipedia is not much help, either. I also skimmed the seventh chapter of the Campbell biology book, about the structure and function of the cell membrane, but there was no clue.
More generally, I have found examples of enzymes that is inhibited only in one direction, such as F1-ATPase (even without the inhibitory epsilon subunit) with its mechanism of ADP inhibition, which primarily affect ATP hydrolysis and not ATP synthesis. I just have not found examples of this in passive transporters specifically.
Furthermore, is the mechanism of unidirectional inhibition inherent to the transporter domain itself, or does it require a separate domain, as in the case of the voltage-gated ion channels, to sense the gradient flowing in the other direction and then inhibit the transporter domain?
Is there even an universal mechanism?
My guess for an universal mechanism would be the former, as I am aware of the basic kinetics of the active ABC transporters, in that they preferentially open to one side of the membrane.