I always though compliance of a vessel is a thing that prevents systolic pressure to goes up a lot and also prevents the diastolic pressure to goes down a lot, and that works because in arteriosclerosis we see that because of low compliance the systolic pressure goes up and diastolic pressure goes down therefore pulse pressure increases,

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but I see a graph that shows systolic and diastolic pressure changes with age, we say with aging the compliance of vessels come down,but as you see in the below graph, both diastolic and systolic pressure goes up(I also find this sentence in the textbooks), why does diastolic pressure go up? Why it doesn’t go down like with arteriosclerosis? And also pulse pressure goes up with aging.

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Both of the graphs are from Guyton, also I have this problem: What factors affect systolic and diastolic pressure? I search a lot but didn’t find anything.

  • $\begingroup$ The first figure does not show diastolic pressure going down with arteriosclerosis, does it? $\endgroup$
    – Bryan Krause
    Aug 8, 2022 at 14:10
  • $\begingroup$ I don’t see too, I just write what I’ve heard in the class. unfortunately there is nothing about it in guyton. $\endgroup$
    – J122
    Aug 8, 2022 at 15:17
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    $\begingroup$ Welcome to the site. Please take a tour and visit the help center for what makes a good question/answer on this site. This site values questions that show some evidence of previous research, of which there is plenty into blood pressure and arteriosclerosis etc. I'm not sure on your question here. The top graphs are point measurements of actual pressure over a single pulse-wave, but the second is average pressure with age. Why wouldn't the overall pressure increase with arteriosclerosis/age? $\endgroup$
    – bob1
    Aug 10, 2022 at 3:36
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    $\begingroup$ It would help if you were to focus down to a single question. At the moment it seems you want a complete rundown of all conditions that affect every aspect of blood pressure, that's too broad for this site's format. Please narrow to a single question, then ask any follow-up questions in their own threads. $\endgroup$ Aug 11, 2022 at 13:25


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