In "[Genomics: A Very Short Introduction]" by John Archibald, the author discusses the DNA sequencing:
In reality, most nuclear genomes are a mixture of unique sequences and short and long repeats of various kinds, and researchers have developed ways of dealing with the issue. One approach is to obtain sequences from both ends of the randomly selected DNA fragments (see Figure 6), and to have the algorithm keep track of these so-called ‘paired ends’ and the distance between them (which is known because the genomic DNA was size-selected prior to library construction and sequencing). This improves the chances of being able to anchor the sequence data from each DNA fragment onto the genome. It is also common to perform multiple sequencing runs using DNA that has been sheared to different sizes (e.g. 2, 10, and 50 Kbp); this makes paired-end data even more effective in overcoming the problems associated with repetitive DNA.
I don't have enough knowledge about this topic, and I'm not sure of the exact meaning of "run" in this context. Does it mean "performing the process of sequencing multiple times" or "generating multiple sequences"?