I was thinking about using bilateral decortication in rodents (preferentially mice) to study the roles of certain brainstem areas in cognitive tasks in the absence of cortex. However almost all studies I could find with bilaterally decorticate rodents date back to at least the 1980s if not older. Is there a specific reason for this? Also, do you guys know of any relatively recent protocol for bilateral decortication in rodents?

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    $\begingroup$ Probably seen as a bit ethically questionable these days, without a particularly keen need/reasoning. Also techniques are preferred to be able to temporarily turn parts of the brain on and off, for example with optogenetics, DREADDs, etc. $\endgroup$
    – Bryan Krause
    Sep 3, 2022 at 0:35
  • $\begingroup$ @BryanKrause - this is akin to answer in comment. Insert a few links here and there and (at least) I would be happy with this answer. Otherwise you might wish to delete the comment? $\endgroup$
    – AliceD
    Sep 5, 2022 at 7:30


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