A few years ago, the Thought Emporium published a video (https://www.youtube.com/watch?v=aoczYXJeMY4) in which he refers to a study in which they mix plasmid DNA with Chitosan and feed it to mice to express LacZ gene so the mice's intestines could produce Lactase (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717060/?fbclid=IwAR0K7C8GounA9DZwkIRm8qSGMSKuo_uHsl8-2qd2fGjnIgn5SkPXddcODsY).
Thought Emporium then shows a plasmid that could do the same for humans. In the plasmid (image below), there is this "SMAR" sequence. He says this acts like an ori but for mammalian cells.
I don't understand how SMAR functions like an ori. When I look up SMAR, it seems to be a protein structure in the nucleus rather than a gene. And the original paper doesn't mention SMAR at all.
What is SMAR? How does it function? Why does it act like an ori?