The way I understood immune system is that:
- phagocytes detect viruses and present it on their surface and become antigen presenting cells.
- Then, T-helper cells try to bind to these phagocytes that have antigen on their surface and found, T-helper cells become effector T-helper cells which then cause the activation of B-cell.
Question 1: If phagocytes can't detect virus, that means T-helper cells wouldn't be activated(there would be no process of cytokines) and if no cytokines, B-cell activation wouldn't happen. and if no B-cell activation, no antibodies releasing. So This means unless phagocytes detect the virus, B-cell activation doesn't happen, but this would be too bad, because if B-cell activation depend on the phagocytes finding the virus, this means if innate immune response fails, adaptive also fails. I'm wondering when would still B-cell be activated even without phagocytes finding the virus in the first place ? otherwise, B-cell always depending on phagocytes would be too bad...
Question 2: Am I right that B-cells can detect/identify the virus that couldn't have been identified by the phagocytes ? I think so, because phagocytes have general PRR which sometimes might be unable to detect, but B-cells have more combinations of variable portion proteins that could detect more stuff ?