I learnt that two factors for NMDA receptor channels opening are:

1)Binding of glutamate

2)Depolarization of postsynaptic cell (to remove the Mg+2 block)

Given that depolarization starts in axon hillock and NMDA receptors are on dendrites, how does it all work?

  • $\begingroup$ "depolarization starts in axon hillock" - this is not true, why do you think this? $\endgroup$
    – Bryan Krause
    Dec 10, 2022 at 17:35
  • $\begingroup$ Seemingly I confused the term with action potential. So NMDA receptors need a depolarization which is below +30? $\endgroup$
    – Taylan
    Dec 10, 2022 at 17:43
  • $\begingroup$ Yes, that's correct. Also read about backpropagating action potentials. $\endgroup$
    – Bryan Krause
    Dec 10, 2022 at 17:45
  • $\begingroup$ Alright, I will. Thank you! $\endgroup$
    – Taylan
    Dec 10, 2022 at 17:48


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