0
$\begingroup$

Maglev centrifugal pumps have been used in the latest ventricular assist devices (VAD) and several experimental total artificial hearts (TAH). Compared to previous generation pumps, maglev pumps don’t have any moving parts (joints, bearings, etc.), which greatly reduces the risk of coagulation. However, the risk of blood clotting is still not eliminated. Normally the bloodstream is lined with vascular endothelial cells, which secret anticoagulants to prevent blood clotting in the vessels.

So I come up with an interesting idea. Can we prevent blood clotting by growing a single layer of endothelial cells on the surface of the stator and rotor? We have successfully cultured many animal cells. By adding a few animal cells and culture medium into a bottle, the cells will grow into a single layer of cells along the smooth surface of the bottle. Because there is no moving part inside maglev pumps, it would not be difficult for endothelial cells to adhere onto the surfaces. The blood can serve as an ideal culture medium which provides nutrition and carries away metabolic wastes. So if we can grow endothelial cells on VAD or TAH, will it eliminate the need to take anticoagulants?

$\endgroup$
5
  • $\begingroup$ "By adding a few animal cells and culture medium into a bottle, the cells will grow into a single layer of cells along the smooth surface of the bottle" - oh really? What makes you think that? $\endgroup$
    – Bryan Krause
    Jan 23 at 21:43
  • $\begingroup$ So what else does it take? $\endgroup$
    – 哲煜黄
    Jan 24 at 9:18
  • $\begingroup$ The answer to that question would fill textbooks. $\endgroup$
    – Bryan Krause
    Jan 24 at 16:16
  • $\begingroup$ I know there are many other things required like temperature, pH, disinfectants and growth factors, but I don’t think this is a big problem inside our own body. $\endgroup$
    – 哲煜黄
    Jan 25 at 11:58
  • $\begingroup$ Our body is the best cell culture. $\endgroup$
    – 哲煜黄
    Jan 25 at 11:59

0

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.