B- actin is used a great deal for quantitation of liver lysates. What other alternatives are there for WB analysis? should we opt for GAPDH or tubulin?
Use a total protein stain. Irrespective of tissue type, normalising your immunoblot signal using a total protein stain is a good, probably superior, approach (ref1, ref2, ref3). Many journal guidelines now strongly encourage the practice;
Normalize signal intensity to total protein loading (assessed by staining membranes for total protein) whenever possible. “House-keeping” proteins should not be used for normalization without evidence that the experimental manipulations do not affect expression.
If you really need to use single protein loading control, confirm that it's stable in your hands; the abundance of any given protein in a tissue could still be perturbed by your experimental conditions.
Confirming consistent loading of your lanes using a total protein stain can help to confirm that your loading control is consistent in your experiment. I generally collect both total protein signal and a loading control but will only use the latter if a reviewer is being difficult.