How long does mRNA delivered therapeutically to cells last in the human cell once it's gotten there? I've seen sources say that endogenous mRNA lasts around 8-10 hours in humans, but wasn't sure if anything about the currently used mRNA therapeutics extended their halflife in vivo. For example, some of the COVID vaccines used a human α-globin fragment for one of their UTRs, and similar specifically selected UTRs show up in mRNA therapeutics presumably to enhance either transcription or stability.

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    $\begingroup$ This is a very broad question which is unlikely to be answered in this form. Can you please restrict yourself to one question at a time? $\endgroup$
    – Chris
    Commented Nov 2, 2023 at 18:49
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    $\begingroup$ @Chris Understood, question scope restricted, thanks $\endgroup$
    – Gumpf
    Commented Nov 2, 2023 at 19:53
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    $\begingroup$ mRNA half-life varies markedly, with a variety of stabilising features (or the reverse). Viral structural RNAs that act as mRNA differ again. Regardless, mRNAs are not transcribed. If you want to know how long a particular viral RNA or a particular vaccine RNA persists, that would be a valid question. Likewise the purpose of introducing particular sequences in vaccines. But at the moment your question seems to me misconceived. $\endgroup$
    – David
    Commented Nov 2, 2023 at 20:07


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