In a nutshell, there are two major differences:
Species range: BioGRID integrates multiple species' protein-protein interaction (PPI) data, whereas HPRD focuses mainly on Human data.
Functionality: HPRD has some GUI tools that can interact directly with it's database (e.g. BLAST - for searching proteins and their binding partners via sequence alignment) whereas BioGRID is mostly just a database.
In bold are the unique features of each database.
The Human Protein Reference Database represents a
centralized platform to visually depict and integrate information
pertaining to domain architecture, post-translational modifications,
interaction networks and disease association for each protein in the
human proteome. All the information in HPRD has been manually
extracted from the literature by expert biologists who read, interpret
and analyze the published data. HPRD has been created using an object
oriented database in Zope, an open source web application server, that
provides versatility in query functions and allows data to be
FAQ HPRD: Why did you decide to develop yet another database instead of integrating other existing databases?"
We believe that biological databases are still in their early stages
and no protein database can be considered as an established standard.
We feel that a variety of databases trying to solve problems in
diverse ways provide the biologists the possibility of choosing their
favorite. Our approach is radically different from existing databases
and we want to offer biologists the possibility of choosing instead of
imposing one database by default. Besides, most of the databases are
automated and ours is manually curated to avoid errors. We are also
trying to provide information that few other databases provide.
The Biological General Repository for Interaction Datasets (BioGRID)
is a public database that archives and disseminates genetic and
protein interaction data from model organisms and humans
(thebiogrid.org). BioGRID currently holds over 720,000 interactions
curated from both high-throughput datasets and individual focused
studies, as derived from over 41,000 publications in the primary
literature. Complete coverage of the entire literature is maintained
for budding yeast (S. cerevisiae), fission yeast (S. pombe) and thale
cress (A. thaliana), and efforts to expand curation across multiple
metazoan species are underway. Current curation drives are focused on
particular areas of biology to enable insights into conserved networks
and pathways that are relevant to human health. The BioGRID 3.2 web
interface contains new search and display features that enable rapid
queries across multiple data types and sources. BioGRID provides
interaction data to several model organism databases, resources such
as Entrez-Gene, SGD, TAIR, FlyBase and other interaction
meta-databases. The entire BioGRID 3.2 data collection may be
downloaded in multiple file formats, including IMEx compatible PSI MI
XML. For developers, BioGRID interactions are also available via a
REST based Web Service and Cytoscape plugin. All BioGRID documentation
is available online in the BioGRID Wiki.