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There are two pathways in blood clot fromation; the extrinsic pathway and the intrinsic pathway.

The extrinsic pathway is faster than intrinsic pathway because it has less number of steps. So, why do we need intrinsic pathway then?

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    $\begingroup$ in general there are very few functions in organisms which have a single mediation - redundancy is typical in biology at the level of gene action. it makes the system robust $\endgroup$ – shigeta Jan 15 '14 at 19:16
  • $\begingroup$ This question embodies two unjustified assumptions that keep cropping in questions. 1. How do you know that a pathway with fewer steps is faster? You don't. It depends on amounts of enzymes and their catalytic characteristics. 2. How do you know that a slightly faster faster pathway will have an advantage? Again you don't. Other factors may be limiting or more important. Moral: when you have written your question out, read it and consider the validity of your assumptions. $\endgroup$ – David Nov 25 '18 at 20:07
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In short: The extrinsic cascade reacts to damages of the blood vessel, the intrinsic pathway reacts to damages of the walls. But as with all things, the long version is ways more complicated:

The extrinsic pathway is activated when you damage tissue and factor VII come in contact with tissue factor (also known as factor III). Tissue factor is located in the membrane of the cells and is only released when the cells are damaged. Then the cascade starts and delivers a very fast large amounts of active thrombin, which then converts fibrinogen to fibrin to build a block of the damaged blood vessel. The step from the thrombin is common between both pathways.

The intric pathway is also called the "contact pathway", which starts when the factor VII comes in contact with collagen or anionic surfaces. The main advantage of this pathway is the strong amplification of the initial signal from the intrinsic pathway by a factor of about 1000 fold. The intrinsic pathway is also co-activated by active thrombin (which stands at the end of the cascade) meaning it is also a powerfull feedback loop to make the initial reaction much stronger. This also overcomes weak activation which where the active thrombin will be inactivated by Tissue Factor Pathway Inhibitor. The coagulation cascade has a pretty nice article in the Wikipedia.

Interestingly it is now believed, that the start of the intrinsic pathway plays no or almost no role in vivo. There are people which "suffer" from a deficiency in factor XII which is necessary to start the intrisic cascade. These people have absolutely no problems with their coagulation, so the first steps are not necessary (any more?). This article presents findings, that it stabilizes a thrombus:"The intrinsic pathway of coagulation is essential for thrombus stability in mice." Here are some further articles about the intrinsic pathway:

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  • $\begingroup$ Do you mean extrinsic pathway by "initial signal"? $\endgroup$ – Rafique Jan 15 '14 at 17:28
  • $\begingroup$ Nope, ny initial signal I mean the initial signal from the intrinsic pathway. Activation of Factor XII which in turn activates Factor XI and so on. Each step of the cascade magnifies the signal. $\endgroup$ – Chris Jan 15 '14 at 19:12
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The extrinsic pathway is activated by extrinsic trauma , that makes blood escape out from the vascular system , and then after the formation of a small amount of fibrin , a substance called Tissue Factor Pathway Inhibitor ( TFPI ) is released , this inhibitor prevent more activation of factor x , it’s thought that TFPI is responsible for preventing more un-needed fibrin , but if the injury need more fibrin to cure , at this point the intrinsic pathway will be activated to form more needed fibrin

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  • $\begingroup$ Welcome to SE Biology. On this site we're looking for answers in which explanations or assertions are supported by references, preferably with links. Without these neither the poster nor anyone else can tell whether or not you are correct, or learn any more about the topic. See the Help for "how do I write a good answer?". $\endgroup$ – David Nov 25 '18 at 20:32

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