If father has hemophilia, mother is a carrier of the disease, then what is the probability of having a normal daughter ?
My question: Should the probability of having a daughter be also multiplied ? Should the answer be 0.5 or should it be 0.25 ?
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1$\begingroup$ Unfortunately, the question is ambiguous. $\endgroup$– Chinmay KanchiJan 25, 2014 at 8:11
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$\begingroup$ @ChinmayKanchi umm..I am not able to understand how this is ambiguous.Could you please elaborate ? $\endgroup$– user4058Jan 25, 2014 at 9:26
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1 Answer
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I can't understand what you mean by "Should the probability of having a daughter be multiplied?" But yes, the probability of having a normal daughter is 0.25, but she will be a carrier like her mother.
Let H represent normal allele for blood clotting (dominant); h represent allele for hemophilia, XY represent the male chromosomes and XX represent the female chromosomes.
Parental Phenotypes :
Normal female(carrier) x Hemophiliac male
Parental Genotypes (2n) :
X(H)X(h) x X(h)Y
Gametes (n) :
X(H) X(h) x X(h) Y
Possible Outcomes :
X(H)X(h) - A normal female, carrier.
X(H)Y - A normal male.
X(h)X(h) - A hemophiliac female.
X(h)Y - A hemophiliac male.
So probability of having a normal daughter, that is X(H)X(h) is 0.25.
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1$\begingroup$ I couldn't find a way to write superscripts, so I put the alleles in parenthesis. Its usually written in superscript. Hope this helps. :) $\endgroup$ Jan 25, 2014 at 10:48