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I know that it has transcellular activity i.e. it can pass through neighbouring cells. However, I am not completely sure if it does not have paracellular activity, see this:

H. pylori did not induce any modification of the paracellular pathway (R = 148 ± 10 versus 174 ± 16 Ω · cm2; JNa = 4.16 ± 0.44 versus 3.51 ± 0.41 μEq/h · cm2; JMan = 0.081 ± 0.01 versus 0.058 ± 0.009 μmol/h · cm2), nor did it modify J3H-HRP (2,201 ± 255 versus 2,110 ± 210 ng/h · cm2 for H. pylori-infected and control cells, respectively). However, in the presence of H. pylori, we observed a significant increase in JHRPi (520 ± 146 versus 171 ± 88 ng/h · cm2). This effect was not dependent of the cag status of the strain and was not reproduced by the sonicates or the culture supernatants.

Is there any evidence that Helicobacter pylori has paracellular activity?

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I found no evidence for paracellular movement.

Some notes of mine

  • Mucinase $\to$ lophotrichous flagella $\to$ Transcellular (actin fibrils, tails) movement
  • ICF Vacuolating cytotoxin (VacA) $\to$ altered T-cell function $\to$ damages epithelial cells, disrupts tight junctions and causes apoptosis.

I think the latter point makes transcellular momevment possible. I see no way how paracellular movement would be possible.

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