what kind of Pathway mediates nitroglycerin-induced relief from angina pectoris,please provide some idea...
The effect of nitroglycerin on the cardiac tissue is similar to nitric oxide (NO), which forms in the endothelium of blood vessels from arginin metabolism products.
So, the general scheme can look like this:
R-NO2 is converted to R-NO outside of the cell (glutathion-SH-dependent reaction). NO is lipophilic and rapidly penetrates into the cell where it activates guanylate cyclase. From this moment you can see the resulting influence on myosin and actin on this picture: