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I am thinking how CVC in lungs lead to the left-sided heart failure.

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I think CVC lead to Pulmonary congestion and edema. They produce heavy, wet lungs.

Pulmonary changes include

  1. perivascular and interstitial edema, particularly in the interlobular septa;
  2. progessive edematous widening of alveolar septa; and
  3. accumulation of edema fluid in alveolar spaces which contain Hemosiderin and microhemorrhages

Now, the progression of the disease to heart should be discussed. I am not sure if hemosiderin can go directly from lungs to heart or if it has to travel through circulation and then to left-side of lung.

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