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Can someone clearly explain me the differences between STRING and I2D(Interlogous interaction database) ? What does each database do best ? Which database is better for what kinds of studies etc ?

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I just looked and it seems I2D use the PPI from 5 organisms to predict interactions in those organisms, which have not yet been experimentally demonstrated, so its interolog PPI prediction tool by design (http://genomebiology.com/content/pdf/gb-2007-8-5-r95.pdf), where as STRING can be used to see what proteins are known to interact with a given protein, and what evidence is present for a particular interaction, which you then get a (confidence like) score.

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  • $\begingroup$ So I2d is STRING + some interologous interactions without any scoring parameter. Anything wrong in what I just said $\endgroup$
    – user6417
    Jun 2, 2014 at 12:54
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    $\begingroup$ Yes, that's essentially correct although STRING is a lot more comprehensive in terms of the number of species it has PPI data for. $\endgroup$
    – Behzad Rowshanravan
    Jun 2, 2014 at 17:26

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