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Is there any academic reference that shows α-tubulin is around 50-55 kDa? The only thing I found is some data sheets from companies. I need the real reference.

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    $\begingroup$ The data sheet is a good enough reference. They must have showed a gel picture also. If not then find details of the protein in Uniprot. $\endgroup$
    – WYSIWYG
    Jun 10, 2014 at 6:48

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This is not so easy to answer, since alpha-tubulin has at 10 known genes in this family (data from Ensembl):

  • TUBA1A tubulin, alpha 1a
  • TUBA1B tubulin, alpha 1b
  • TUBA3E tubulin, alpha 3e
  • TUBA3D tubulin, alpha 3d
  • TUBA4A tubulin, alpha 4a
  • TUBAL3 tubulin, alpha-like 3
  • TUBA1C tubulin, alpha 1c
  • TUBA3C tubulin, alpha 3c
  • TUBA8 tubulin, alpha 8
  • TUBAL3 tubulin, alpha-like 3

You can go on the site linked above and choose any of the proteins. I checked TUBA1A, and get a length of 451 amino acids and a weight of approximately 50,1 kDa.

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The paper titled Identification of α-tubulin as a granzyme B substrate during CTL-mediated apoptosis mentions it as 51KDa and the paper titled Carboxy-terminal amino acid sequence of α-tubulin from porcine brain mentions it as 55,000 Da. Hope that suffices.

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