0
$\begingroup$

since the title seems self explanatory; It would be nice if anybody could provide a reference. I'm looking for a paper that I belive stated around 1.5 Mb but anything above will be cordialy welcomed. thanks a lot

$\endgroup$
2
$\begingroup$

I haven't found 1.5 Mb, but 1 Megabase. This is the case for the shh gene in chicken, where the enhancer element is located 1 Mb upstream. The original article can be found here:

There are two reviews which are also interesting in this context:

$\endgroup$
  • $\begingroup$ thanks. I also have encountered 1 Mb and distances slightly above, but I'm specifically interested in the longest known functional distance in cis. it is not as easy as I thought since I have spend now several hours on ncbi/pubmed ... $\endgroup$ – pidoretroma Jul 4 '14 at 13:59
  • $\begingroup$ I can have an additional look later today. Do you have any idea in which organism or for which gene this has been described? $\endgroup$ – Chris Jul 4 '14 at 14:05
  • $\begingroup$ unfortunately i don't. i may belive belive it was in M.m - but then again if I remembered properly I would have found it by now. thanks again anyway $\endgroup$ – pidoretroma Jul 4 '14 at 14:08
  • $\begingroup$ this paper "Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation" at least states finding interaction-distances in the range of megabases... and leaves it at that. $\endgroup$ – pidoretroma Jul 4 '14 at 16:07
  • $\begingroup$ I stumbled upon a few of these claims but they never show data or have references for it. $\endgroup$ – Chris Jul 4 '14 at 16:48

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.