since the title seems self explanatory; It would be nice if anybody could provide a reference. I'm looking for a paper that I belive stated around 1.5 Mb but anything above will be cordialy welcomed. thanks a lot


1 Answer 1


I haven't found 1.5 Mb, but 1 Megabase. This is the case for the shh gene in chicken, where the enhancer element is located 1 Mb upstream. The original article can be found here:

There are two reviews which are also interesting in this context:

  • $\begingroup$ thanks. I also have encountered 1 Mb and distances slightly above, but I'm specifically interested in the longest known functional distance in cis. it is not as easy as I thought since I have spend now several hours on ncbi/pubmed ... $\endgroup$ Jul 4, 2014 at 13:59
  • $\begingroup$ I can have an additional look later today. Do you have any idea in which organism or for which gene this has been described? $\endgroup$
    – Chris
    Jul 4, 2014 at 14:05
  • $\begingroup$ unfortunately i don't. i may belive belive it was in M.m - but then again if I remembered properly I would have found it by now. thanks again anyway $\endgroup$ Jul 4, 2014 at 14:08
  • $\begingroup$ this paper "Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation" at least states finding interaction-distances in the range of megabases... and leaves it at that. $\endgroup$ Jul 4, 2014 at 16:07
  • $\begingroup$ I stumbled upon a few of these claims but they never show data or have references for it. $\endgroup$
    – Chris
    Jul 4, 2014 at 16:48

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