The plateau phase is maintained by influx of calcium and outflux of potassium in the second stage:
My conjecture is that calcium transforms between two phases
- ionated phase (free calcium from i/c SR and e/c Ca-ATPase)
- non-ionated phase (bound to some proteins).
The initial form can be ionated. The process of deionisation occurs only in all-or-nothing cases - I see no evidence that this process can be continuous in my data. My another conjecture why this deionisation can occur is because of the vortexes in the diastolic phase of ventricles (T wave; blood bouncing back to the tricuspid valve).
Which sources can correspond to this non-ionated calcium more? My conjecture is e/c Ca more because longer travelling distance and entry involves accelerative movement. Actually, this can differ depending on the situation at hand.
The accelerative movement can also contribute more to ionisation process so the situation can be reverse in some cases. How is Calcium released from Sarcoplasmic reticulum? Steadily or in accelerative motion or in a vortex.
How are Calcium forms regulated during action potential of myocardial cell plateau phase?
Keywords: Local Ca2+ signaling in health and diseases.