Where can I find a list of enzyme cofactors and/or co-enzymes, ordered by how common they are?

For example, $O_2$, $H_2O$, $ATP$, $ADP$, $NAD$, should be ranked in the first places, because they participate in most reactions.

  • 2
    $\begingroup$ $H_2O$ is not a cofactor for any enzyme. $\endgroup$
    Commented Jul 23, 2014 at 15:20
  • $\begingroup$ Also oxygen cannot be called a cofactor. It is just an electron acceptor- in a way a co-enzyme. $\endgroup$
    Commented Jul 23, 2014 at 15:32
  • $\begingroup$ @WYSIWYG I have edited to include co-enzymes. $\endgroup$
    – a06e
    Commented Jul 24, 2014 at 13:20

2 Answers 2


Check this out. This resource lists organic cofactors and the associated enzymes. See the wikipedia page also.

Many metals also serve as prosthetic groups in enzymes. They include- Magnesium, Manganese, Iron, Cobalt, Nickel, Copper, Zinc, Molybdenum.

FeS clusters are also an important part in many important enzymes in mitochondria and plastids.



coenzymes are organic molecules that are required by certain enzymes to carry out catalysis.


CoFactor - The organic enzyme cofactor database of EBI


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