In histology we know that epithelium tissue isn't vascularized so it takes the nutrition from Lamina propia (CT) via diffusion and in other hand we know all epithilial cells have tight junction which inhibits the flow of substance so how can it diffuse nutrients between themselves because of the tight junction how can they distribute nutrients, same way in capillaries which are endothelium how interstitial fluid passes throw endothelial cells because of thier tight junction?

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    $\begingroup$ Most epithelial cell layers a thin so that is not a problem. The epithelial layer of the skin gets less nutrients the further their distance to the basal layer is and eventually these cells die and form the horny layer of out skin. $\endgroup$
    – Chris
    Sep 2, 2014 at 9:15

1 Answer 1


Tight junctions function to occlude the baso-apical flow of small molecules. However, tight junctions do not always completely seal a cell's lateral surface. In addition to regulating diffusion, tight junctions promote cell polarity. Establishment of polarity and prevention of water loss are the major roles of tight junctions in stratified squamous epithelia.

In simple epithelia, transcytosis allows the flow of molecules through a cell with tight junctions. However, stratified squamous cells do not use transcytosis for nutrient supply.

In the stratum granulosum, skin cells lose their nuclei and become non-viable. In the stratum lucidum, an oily layer is produced by exocytosis.

It is the loss of nuclei, organells, production of an oily layer at the stratum granulosum and lucidum that contributes most to the death of skin cells, not the limits of nutrient diffusion.

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