I’ve been intrigued by gene duplication and want to learn more about it.
I’ve read the following from here:
several studies suggest that the proportion of duplicated genes retained in vertebrate genomes is much higher than is predicted by this model [4-6]. This has led to the suggestion of an alternative model whereby complementary degenerative mutations in independent subfunctions of each gene copy permits their preservation in the genome, as both copies of the gene are now required to recapitulate the full range of functions present in the single ancestral gene. This was formalized in the Duplication-Degeneration-Complementation (DDC) model [7] in a process referred to as subfunctionalization.
Can someone explain this? What is meant by “both copies of the gene are now required to recapitulate the full range of functions present in the single ancestral gene”?
Can you suggest any other good articles on gene duplication?