These antibiotics include
- amoxicillin + acidum clavulanicum (beta-lactam, inhibit cell wall synthesis, broad specturm, 3rd gen aminopenicillin) / last part preventing the resistance
- ceftriaxone (3rd gen cephalosporine, inhibit cell wall synthesis, broad spectrum)
- clarithromycin (macrolide, inhibit protein synthesis by binding to ribosomal subunit S50)
used regularly for cyclic middle ear infections for years during the childhood - ages 2-10 for a patient with untreated celiac disease.
I am thinking what kind of immunosuppression can this lead to. I think it mostly conquered by suppression of adaptive immune system. Little lowered innate immunity lowered too.
I am especially interested in the antigen-presenting cells (mostly dendritic cells) and their function in an immunosuppressed patients of the antibiotics.
There may be other factors which I have not mentioned related to this kind of immunosuppression. Feel, free to propose.
How can dendritic cells work in an immunosuppressed patients?
You can assume any combination of cases for the three antibiotics: 8 possible cases. For instance,
- (1) and (2) high antibiotic resistance, and only susceptible to (3)
- High antibiotic resistance to (1)-(3)
Possible cases which reminds
- this immunosuppression can remind this one: immune reconstitution syndrome like in HIV but milder