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Huntington's disease can hit at any age, although it tends to hit middleaged people most often. What is the youngest and oldest person that has exhibited Huntington's?

Clarification: By oldest I mean with no prior symptoms until the age.

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Huntington's disease may become symptomatic starting from as low as 2 years old [1] and rarely after 55 years old [2] (yet there is evidence of onset at 65 years old [3] and even more according to newer studies).

Copyright © 2004, The American Society for Experimental NeuroTherapeutics, Inc.

Figure: Copyright © 2004, The American Society for Experimental NeuroTherapeutics, Inc.
Richard H. Myers. Huntington’s Disease Genetics. NeuroRx. Apr 2004; 1(2): 255–262. doi: 10.1602/neurorx.1.2.255. PMCID: PMC534940

Factors [4]:

  • CAG number (65%-71% of the variance in age of onset)
  • siblingship (11%-19%)

[...] paternal age is negatively associated with age at onset of HD (Huntington's disease), particularly among subjects who inherit the mutant gene from grandfathers [5].


References:

  1. Huntington's Disease Society Of America. What is Huntington's Disease (HD)? Available from http://www.hdsa.org/about/our-mission/what-is-hd.html (accessed 26.10.2014)
  2. National Institute of Neurological Disorders and Stroke. Huntington's Disease: Hope Through Research Available from http://www.ninds.nih.gov/disorders/huntington/detail_huntington.htm (accessed 26.10.2014)
  3. Myers RH, Madden JJ, Teague JL, Falek A. Factors related to onset age of Huntington disease. Am J Hum Genet. 1982 May;34(3):481-8. PMID: 6211092. Full text available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1685335/
  4. Rosenblatt A, Brinkman RR, Liang KY, Almqvist EW, Margolis RL, Huang CY, Sherr M, Franz ML, Abbott MH, Hayden MR, Ross CA. Familial influence on age of onset among siblings with Huntington disease. Am J Med Genet. 2001 Jul 8;105(5):399-403. PMID: 11449389. Available from http://www.ncbi.nlm.nih.gov/pubmed/11449389
  5. Farrer LA, Cupples LA, Kiely DK, Conneally PM, Myers RH. Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting. Am J Hum Genet. 1992 Mar;50(3):528-35. PMID: 1531729. Full text available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684271/
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  • $\begingroup$ Any exact dates? Like a child of 612 days exhibiting it? Or a woman of 72 years? $\endgroup$ – MikhailTal Oct 26 '14 at 18:02
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I first experienced Huntington's Chorea at 7-1/2 years of age. My father took me to Vanderbilt Hospital in Nashville, TN where it was confirmed by testing. I am now 71-1/2 years old, and have suffered Rheumatic Fever, a stroke, 4 heart attacks, and atrial fibrillation, along with many other less serious diseaes. I still have occasional bouts of Chorea, but am leading a mostly normal life. During my earlier life at age 60, I completed a Bachelor of Science and an M.B.A. degree, so my reasoning faculties and ability to organize and study successfully are still intact. I may be on borrowed time, but don't worry about it.

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