If a culture or sample of cells is such they all have no apoptosis mechanisms yet they have not been at present determined to be cancerous ; given such a cell culture is there a way to determine by their byproducts or how they signal themselves or other cells that they have no 'working' apoptosis mechanisms?

  • $\begingroup$ I am not sure, if I understand your question. You want to know if (or how) cells with non-functional apoptosis (however this happened) know themselves that their apoptosis is no working? And how they communicate this to other cells? $\endgroup$
    – Chris
    Commented Nov 5, 2014 at 8:40
  • $\begingroup$ If cells with non-functioning apoptosis mechanisms can be detected by some type of test this would indicate a possible tumor as tumor cells don't have functioning apoptosis mechanisms. ( at least that's what somebody else said on this exchange) $\endgroup$
    – user128932
    Commented Nov 14, 2014 at 3:23
  • $\begingroup$ Is there a way to test a cell or cell culture in some way simpler than analysing their genome to determine if they have actively working apoptosis mechanisms? Does a cell with a working apoptosis mechanism 'produce' or 'give off' certain signals or chemical signatures that can be detected by some 'test'? $\endgroup$
    – user128932
    Commented Nov 17, 2014 at 5:49
  • $\begingroup$ I am not aware of any. Since apoptosis relies on signalling towards it, you can only try to trigger it and see what the outcome is. Probably nothing, that we want to try on a large scale. $\endgroup$
    – Chris
    Commented Nov 17, 2014 at 7:20
  • $\begingroup$ Could a non-harmful virus or bacteria that normal cells could survive but would effect a cell with no apoptosis mechanism in a detectable way? $\endgroup$
    – user128932
    Commented Nov 17, 2014 at 16:27


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