Dosage compensation is used to make up for different copy numbers of the major sex chromosomes in males and females (One X or Z chromosome in one and two in the other). Two main mechanisms of dosage compensation exist, inactivation and upregulation.
But dosage compensation is not entirely perfect, the amount of gene product from an upregulated X/Z-linked genes in the heterogametic sex is not exactly that of the two in the homogametic sex.
On average how well is dosage compensation performed? What is the variance like:
within a single chromosome (between genes)?