2
$\begingroup$

In Wang et al., the authors state on page 663 at the top that

Furthermore, Bax-/- Bak-/- cells were completely resistant to paclitaxel-induced apoptosis.

What's the meaning of the -/- notation? Bax and Bak are proteins involved in apoptosis.

$\endgroup$
8
$\begingroup$

-/- means both copies of the gene (both alleles) are knocked out

$\endgroup$
  • 1
    $\begingroup$ I guess I need to brush up on my molecular biology, but by "both copies" you mean, both copies present during mitosis? $\endgroup$ – TMOTTM Nov 9 '14 at 12:11
  • 3
    $\begingroup$ As chromosomes come in pairs (bar the X chromosome in males), each gene is also present twice. -/- means both are knocked out. $\endgroup$ – AliceD Nov 9 '14 at 12:20

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.