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I read on a vitamin-D product (2000NE) that I should not use calcium and magnesium with it, because it can result crystal formation in the blood. I googled, but find anything about this. Is it true?

(Somehow I doubt it, but I don't know the exact mechanism how vitamin-D works by building bones. Afaik. there are osteoblasts and osteoclasts which constantly build and degrade the Ca-Mg-PO4 depos, and I assume vitamin-D is just a cofactor of an enzyme or it is required to produce a hormone. I never heard of Ca/Mg - vitamin-D cross-reactions...)

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    $\begingroup$ Since vitamin D leads to the absorption of calcium, it can lead to hypercalcemia and calcium precipitation! This is true specially in patients with hyperphosphatemia (ncbi.nlm.nih.gov/pmc/articles/PMC2486454) $\endgroup$
    – Behzad Rowshanravan
    Commented Nov 11, 2014 at 14:36

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Vitamin D does not bind to Calcium. It is a pre-hormone which is converted to calcitriol. Calcitriol has an intracellular receptor (VDR) that, as a heterodimer with Retinoid-X receptor, regulates gene expression.

I guess the "should not be had together" is because of possible over-absorption of Calcium. There are commercially available supplements (e.g. 1, 2) that have Vit-D + Ca + Mg.

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  • $\begingroup$ Additionally both are present in milk, if I remember correctly. $\endgroup$
    – Chris ♦
    Commented Nov 11, 2014 at 14:14
  • $\begingroup$ The exact words were "it forms crystals in the blood with calcium or magnesium" (in Hungarian ofc.). I guess it was just a bad joke of a frustrated worker, I don't know... $\endgroup$
    – inf3rno
    Commented Nov 11, 2014 at 14:29

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