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Can it be that the adult eye can change color? Specifically my question is about a unilateral color change, such that the color of one eye remains constant, while the other changes color over time. Can this happen? Or can it be related to light-scattering, or an illusion of some sort?

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    $\begingroup$ At any rate, personal medical questions are off-topic on Biology.SE. Please consult a medical professional for your particular situation. $\endgroup$ – MattDMo Nov 23 '14 at 21:41
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Short answer: The genes that encode eye color do not change, but the pigments in the eye can change due to external factors like diseases of medication.

Long answer: Yes, it is possible that the eye color of adults can change, and it can also only happen to one eye. It is then called Heterochromia. There are two possibilities for different colored eyes, either congenitial (genetic) or acquired. Since you ask only for eye color changes in adults, we can skip here the genetic reasons, as these show up in kids already. If you are interested in them, have a look into the Wikipedia article on Heterochromia.

The basis for our eye color is genetically determined, changes can later occur due to diseases (so if one experiences a change in eye color, it is always a good idea to consult a doctor) and also due to medications.

The eye undergoing a change in pigmentation can either lighten up or darken.

Fuchs’ Heterochromic iridocyclitis: (also known as Fuchs’ Heterochromic uveitis) The change is caused by an eye infection with different microorganisms like Toxoplasma gondii, Herpes simplex virus or Rubella (an probably others) but it can also have an autoimmune pathology. See reference 1 and 2 for more details.

Horner's Syndrome: This is a syndrome which mostly occurs in kids after damages to some nerves. This can lead to insufficient signals towards the pigment production and heterochromia. Rarely this can occur also in adults, where this is called acquired Horner's syndrome, see reference 3 for details.

Pigmentary Glaucoma: In this disease (also known as Pigment dispersion syndrome) pigment cells from the back of the iris float are seperated from the original place and float through the aqueous humor of the eye where they can produce pigment which over time changes the appearance of the eye. See reference 4 for more details.

Medications: Some of the medications against glaucoma (the prostaglandins latanoprost and bimatoprost) can cause a deeper pigmentation which will not always diminish after the end of the treatment. See reference 5 for more details.

Cancers: Some cancers as melanoma can also cause heterochromia, either when they are darker pigmented that the eye or when they are not pigmented. In both cases they influence the eye color. See reference 6 for more details.

References:

  1. Fuchs' heterochromic cyclitis: review of the literature on the pathogenetic mechanisms.
  2. Associations of Fuchs heterochromic iridocyclitis in a South Indian patient population
  3. Acquired Heterochromia with Horner's Syndrome in Two Adults
  4. Pigment dispersion syndrome and pigmentary glaucoma – a major review
  5. Incidence of iris colour change in latanoprost treated eyes
  6. Diffuse iris melanoma: Report of a case with review of the literature
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  • $\begingroup$ tl;dr The genes that encode eye color cannot change, but the pigments can change due to environmental factors like medicines or disease. $\endgroup$ – jhocking Nov 24 '14 at 13:37
  • $\begingroup$ Short answer: Yes. :-) $\endgroup$ – Chris Nov 24 '14 at 14:02
  • $\begingroup$ you think my summary is worth editing to the top of your answer? I don't have the rep for that $\endgroup$ – jhocking Nov 24 '14 at 15:30
  • $\begingroup$ I can do that, probably not a bad idea. $\endgroup$ – Chris Nov 24 '14 at 15:41
  • $\begingroup$ It should be noted that the opposite can also occur in an acquired manner: one iris can become paler. $\endgroup$ – anongoodnurse Nov 25 '14 at 3:25
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To add what the previous answer did not: not only medicines and disease change the color of your eyes. Aging does that too in most (if not all!) people. Pigmentation is usually lightest in utero and right after birth. Melanin accumulates over time and makes the hair and eyes darker.

This is why many people are born blond (or green/blue-eyed) and become brunette (or brown-eyed) over a period in their lives. It can take days - usually as a baby - or decades, depending on the individual. The rate is determined genetically, i.e. it does not, for instance, depend on how much exposure to the sun you get. Melanin in the skin can do that.

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