1
$\begingroup$

Salbutamol is a very commonly used direct-acting β2-agonist. This suggests me that it is sympatholytic. However, it has sympathomimetic pathways, see PubChem for Sympathomimetic.

I am trying to think the group of Salbutamol. Sympathomimetic or sympatholytic.

How can you classify Salbutamol into a group?

$\endgroup$
3
$\begingroup$

An agonist works with the receptor: a substance that initiates a physiological response when combined with a receptor; in the case of salbutamol (or albutarol in the US) they activate the beta-2 receptor on the muscles surrounding the airways. They are also known as sympathomimetics, as they imitate β2 adrenergics.

A blocker (or antagonist) is one that that blocks the action of endogenous catecholamines; for that reason, they are also called sympatholytic: antagonistic to or inhibiting the transmission of nerve impulses in the sympathetic nervous system.

It appears you have experienced a simple confusion in terms. Salbutamol/albuterol is definitely a sympathomimetic, used extensively on asthma and COPD.

Pharmacology and Therapeutics of Bronchodilators

$\endgroup$
1
  • $\begingroup$ You seem to be right. I read this A short-acting beta-2 adrenergic agonist as beta-adrenergic antagonist which is false. Thank you for excellent answer! $\endgroup$ – Léo Léopold Hertz 준영 Nov 26 '14 at 17:31

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.