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As a freshman biochemistry major, I find myself befuddled by our body's ability to perform complex chemical reactions to break down foreign substances. I can see how we would evolve explicit pathways to deal with substances we would find often in our environment of evolutionary adaptedness, but we also process things we would never have encountered before. How does the human (or any organism's) body do that without explicit programming?

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  • $\begingroup$ Can you comment a little further? Do you mean in the context of immunology, i.e. processing foreign pathogens? Or do you mean processing small molecules, i.e. drugs? $\endgroup$ – jwillis0720 Dec 25 '14 at 8:14
  • $\begingroup$ @jwillis0720, I think he means processing small molecules such as drugs that the body might metabolise in the liver. $\endgroup$ – Kenshin Dec 25 '14 at 8:23
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    $\begingroup$ @jwillis0720 The term for such substances is Xenobiotics. $\endgroup$ – WYSIWYG Dec 25 '14 at 8:56
  • $\begingroup$ you are right. had to refresh my memory :) $\endgroup$ – jwillis0720 Dec 25 '14 at 9:22
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One strategy for xenobiotic metabolism seems to be making a lot of similar enzymes with different substrate specifities. Lets take the cytochrome p450s as an example. These are a class of enzymes with 57 genes identified for humans, and I don't know how many alternative splicing products are made from those genes. As a class, they are responsible for about 75% of drug metabolism and are predominantly found in the liver. They work by using a heme group with a carbon monoxide to add oxygens to xenobiotics. Here is a diagram of the mechanism:

enter image description here

It's been too long since my drug metabolism class to go into more detail on these enzymes, but there are other classes of enzyme that fit this multiple enzyme strategy such as the 2 monoamine oxidases, 5 flavin containing mono-oxygenases, and 4 epoxide hydrolases. So the body doesn't really know how to break down xenobiotics, but has a wide array of enzymes with broad and overlapping substrate specificities that work on whatever they happen to bind to, whether it's an endogenous hormone or pharmaceutical compound or toxin.

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