Why draw blood from veins rather than arteries? Is it more convenient or safer?


3 Answers 3


Veins have several advantages over arteries. From a purely practical standpoint, veins are easier to access due to their superficial location compared to the arteries which are located deeper under the skin. They have thinner walls (much less smooth muscle surrounding them) than arteries, and have less innervation, so piercing them with a needle requires less force and doesn't hurt as much. Venous pressure is also lower than arterial pressure, so there is less of a chance of blood seeping back out through the puncture point before it heals. Because of their thinner walls, veins tend to be larger than the corresponding artery in the area, so they hold more blood, making collection easier and faster.

Finally, it is somewhat safer if a small embolism (bubble in the blood) is introduced into a vein rather than an artery. Blood flow in veins always goes to larger and larger vessels, so there is very little chance of a vessel being blocked by the embolism before the bubble reaches the heart/lungs and is hopefully destroyed. Blood flow in an artery, on the other hand, always moves into smaller and smaller vessels, eventually ending in capilllaries, and there is a chance that a bubble introduced by a blood draw (generally rare) or more commonly an intravenous line (IV) could block a small blood vessel, potentially leading to hypoxia in the affected tissues.

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    $\begingroup$ +1 - all good points. The main risk, though, is bleeding. Puncturing an artery can cause it to bleed until it tamponades, causing a hematoma which can cause ischemia downstream and might compress/damage the nerve in that neurovascular bundle. Because of that, pressure must be applied for a while (longer for larger arteries). Before doing a radial artery stick (common for blood gasses), one should do an Allen's test for collateral circulation. The risks are acceptable for blood gases or monitoring but not for blood collection. $\endgroup$ Commented Jan 18, 2015 at 5:36
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    $\begingroup$ (Oh, btw, the paper deals with cannulation, not just puncture, but the principles are the same.) $\endgroup$ Commented Jan 18, 2015 at 6:23
  • $\begingroup$ Yes, arteries are punctured when arterial blood gas readings are required. Patients then wear compression bandages for days. $\endgroup$
    – matega
    Commented Jan 19, 2015 at 22:34

Right of the bat, veins are superficial so it is much easier to hit a vein than an artery. Arterial sticks are very difficult if you are not practiced at them while veins are much much easier. Also arterial sticks have a very specific purpose usually for example arterial blood gas. Also veins are low pressure compared to the higher pressure of arteries so less chance of bleeding.


Blood is not always drawn from the veins depending on the medical need and situation. For example critically ill ICU patients will often have an arterial catheter placed to provide an accurate measure of blood pressure. Blood is sometimes sampled from this line to provide a more accurate measure of blood gases and cardiac performance.

But the risks of dealing with arterial blood are greater as others have mentioned.


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