After reading the answer to Does our DNA change during our lives?, I was wondering if and how it would be possible to change the structure of the 13 loci that are used in the CODIS database, in such a way that forensic biometrics would not be able to identify/verify you anymore.

I have read about DNA chimeras, and cases exist where a bone marrow transplantation altered the DNA, depending on the sample that was taken. However, are there any other known ways to alter DNA, such as cancer, radiation, etc?

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    $\begingroup$ What do you think will happen, when you alter you DNA in this way? Short: No, it's not possible. $\endgroup$
    – Chris
    Commented Jan 19, 2015 at 9:51
  • $\begingroup$ Well the nuclear plant example is of course ridiculous, but I'm wondering if cancer or aging may have an effect which is of high enough significance to circumvent DNA tests. $\endgroup$
    – Michael
    Commented Jan 19, 2015 at 9:53
  • $\begingroup$ To cause enough mutations to make the DNA a mismatch would assuredly result in the death of the person long before the sample were obtained. The answer is still no with cancer. $\endgroup$ Commented Jan 19, 2015 at 12:26
  • $\begingroup$ @Chris I disagree that it is necessarily impossible. New techniques such as CRISPR-Cas allows for directed mutagenesis of specific loci, and if you can predict in advance the tissue they are obtaining the DNA from, it is not implausible for a modification to be carried out (for example using retroviral-induced modification). $\endgroup$
    – March Ho
    Commented Jan 19, 2015 at 12:58
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    $\begingroup$ I have edited my question to be less opinion-based. I'm looking for scientific sources where it has been proven that it is possible to alter DNA structure of the 13 loci used in CODIS. Bone marrow transplantations are known to alter the DNA structure of the blood significantly. Blood transfusions as well, but here, the impact is temporary. In case you still feel it is too much opinion-based, I'm open for suggestions. $\endgroup$
    – Michael
    Commented Jan 20, 2015 at 12:38


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