I have encountered comparisons of the Michaelis-Menten constant ($K_m$) a few times. Generally speaking if the $K_m$ of an enzyme is higher, then its affinity to its substrate is lower. How does this make sense?
Maybe the maximum velocity ($V_{\mathrm{max}}$) of higher $K_m$ enzymes is higher? Then of course, $K_m$ can have a higher value. Because $K_m$ is the substrate concentration at half of the $V_{\mathrm{max}}$. But I think we cannot determine affinity with $K_m$.