ANF as we know reduce the Na+ uptake and K+ removal in the distal tubules and it also functions as a Vasodialator (?) But again it says that ANF increases the Glomerular filtrate ? But if it is acting has a Vasoldialator (ie, antagonistic to Vasopressin) how is it increasing the GFR ? Shouldnt it lower the GFR ?

ANF - Atrial Natriuretic Factor also called Atrial Natriuretic Peptide

GFR - Glomerular Filtration Rate


ANF (Atrial Natriuretic Factor more commonly known as ANP - atrial natriuretic peptide) squeezes (vasoconstricts) the efferent arteriole. This means the pressure in the glomerulus is higher (like if you squeeze the end of a hose) and so more fluid is squeezed out i.e. the glomerular filtration rate (GFR) is higher. It also dilates the afferent which means more fluid is going in, further increasing GFR (Marin-Grez et al.)


  • $\begingroup$ Why is this answer down voted? $\endgroup$
    – One Face
    Feb 25 '15 at 9:57
  • $\begingroup$ Someone has been downvoting all my answers for whatever reason. Assume they're trying to get me under 4000. $\endgroup$ Feb 25 '15 at 13:53
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    $\begingroup$ @ChrisStronks: Thank you for your feedback. Comments and feedback help improve answers whereas simply down voting leave the author of an answer confused. In the future make sure to leave comments when you down vote to avoid not being helpful. I have improved the answer by explaining acronyms and adding a reference. There isn't a better picture than this which has ANP on it. $\endgroup$ Feb 26 '15 at 9:04
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    $\begingroup$ @AndroidPenguin - you are totally right. Normally I leave a comment. My bad. +1 :-) $\endgroup$
    – AliceD
    Feb 26 '15 at 9:14
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    $\begingroup$ So the summary is that ANP vasodilates the afferent arterioles and constricts the efferect arteriole ? $\endgroup$ Feb 27 '15 at 3:17

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