I was wondering if anybody knows some publication about macro lncRNA (very long unspliced RNAs) or more generally a transcribed RNA that may lead to cis-DNA looping of genomic regions overlapped by the (macro) lncRNA transcript ?


  • $\begingroup$ I didn't actually understand the phenomenon that you are describing. You mean a long RNA binds to different regions of DNA (in cis) causing them to come together? $\endgroup$ – WYSIWYG Feb 25 '15 at 17:15
  • $\begingroup$ It's more the act of transcription of a long RNA that may lead to bring distant chromosome regions closer by the act of 3D DNA conformation. $\endgroup$ – Nicolas Rosewick Feb 25 '15 at 20:16
  • $\begingroup$ I don't think the act of transcription, per-se will bring DNA domains together. It would open up the chromatin. However the "act of transcription" has been said to precede recruitment of Polycomb/Trithorax complexes and these in turn can recruit chromatin remodellers/enhancers etc. $\endgroup$ – WYSIWYG Feb 26 '15 at 5:16
  • $\begingroup$ Thanks. Do you have in mind a recent paper talking about it ? $\endgroup$ – Nicolas Rosewick Feb 26 '15 at 9:42
  • $\begingroup$ I haven't read a recent paper on this. I was doing a project on Polycomb in my UG and that is when I read this in an annualreviews article. It has been 7 years since then. I am sure more research must have been done on this. But in general this concept itself is quite dubious. I can only suggest you directions to look at. Another thing that you can look for is pervasive transcription. $\endgroup$ – WYSIWYG Feb 26 '15 at 9:56

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