In this paper the authors state that the dosage compensation seen in Drosophila is approximately twofold, but they do not provide any source or numbers (as far as I can see) for this. What is the mean degree of dosage compensation in Drosophila (melanogaster)? For example, if X linked genes are, on average, perfectly upregulated the X:AA ratio in males would be 1, while if they are nearly perfectly (but slightly under) upregulated it will be ~0.9.

Here is a similar (but different) question RE perfection in DC in general (here I am specific to Drosophila melanogaster).

  • $\begingroup$ please explain downvote $\endgroup$
    – rg255
    Mar 3, 2015 at 11:16
  • $\begingroup$ I checked for RNAseq experiments in male and female drosophila but couldn't find any. If you can find one study then I can tell what is the mean degree of DC. $\endgroup$
    Mar 3, 2015 at 11:27
  • $\begingroup$ There are studies here and here which explore compensation via the MSL complex (I think Straub et al. has the correct info but they reference the Hamada paper as well). I apologize, I haven't time to read them thoroughly myself, if anyone could give them a look over. $\endgroup$
    – CKM
    May 26, 2015 at 0:24


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