4
$\begingroup$

In this paper the authors state that the dosage compensation seen in Drosophila is approximately twofold, but they do not provide any source or numbers (as far as I can see) for this. What is the mean degree of dosage compensation in Drosophila (melanogaster)? For example, if X linked genes are, on average, perfectly upregulated the X:AA ratio in males would be 1, while if they are nearly perfectly (but slightly under) upregulated it will be ~0.9.

Here is a similar (but different) question RE perfection in DC in general (here I am specific to Drosophila melanogaster).

$\endgroup$
3
  • $\begingroup$ please explain downvote $\endgroup$
    – rg255
    Mar 3 '15 at 11:16
  • $\begingroup$ I checked for RNAseq experiments in male and female drosophila but couldn't find any. If you can find one study then I can tell what is the mean degree of DC. $\endgroup$
    – WYSIWYG
    Mar 3 '15 at 11:27
  • $\begingroup$ There are studies here and here which explore compensation via the MSL complex (I think Straub et al. has the correct info but they reference the Hamada paper as well). I apologize, I haven't time to read them thoroughly myself, if anyone could give them a look over. $\endgroup$
    – CKM
    May 26 '15 at 0:24

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.