6
$\begingroup$

I am looking for examples (if any) of genomic regions which regulates the activity of enhancers, either augmenting or reducing it. Essentially some kind of enhancers (or repressors) of enhancers to make a Russian doll analogy. I know about epigenetic markings but I am really looking at an example of a DNA region directly acting on a enhancer similar to an enhancer acting directly onto a promoter.

I am asking that because I couldn't find any examples and was wondering if I missed such a report/paper.

Improve this question
$\endgroup$
6
  • 1
    $\begingroup$ Do you care if it's from a viral genome? $\endgroup$
    – Atl LED
    Mar 13, 2015 at 14:14
  • $\begingroup$ @AtlLED If it is a DNA virus then that works. I am interested in DNA secondary and tertiary structures. $\endgroup$
    – cagliari2005
    Mar 13, 2015 at 15:38
  • $\begingroup$ It could be possible that certain enhancer regions can bind the regulatory proteins with higher affinity than other enhancer regions, thus surpressing the amount of activation of the genes regulated by the 'lower affinity enhancer region'. $\endgroup$
    – Wolgast
    Mar 30, 2015 at 12:21
  • $\begingroup$ @Wolgast Interesting idea. This would be some kind of gene regulation via competition. I don't know if this actually happens in the cell (i.e. if some TF are in concentration ranges which would provoke such effect) but in any case it is worth looking into this. Thanks. $\endgroup$
    – cagliari2005
    Mar 30, 2015 at 15:33
  • $\begingroup$ Yes indeed. I'm am interested where this will lead you. Let me know if you find anything! :-) $\endgroup$
    – Wolgast
    Mar 30, 2015 at 17:39

1 Answer 1

Reset to default
1
$\begingroup$

If you're looking for a strictly and directly DNA-DNA mediated effect (no histones, no transcription involved) I'd look for sequence effects on chromatin remodelling, modulating access of transcription factors (TFs) to their elements. Something about this might be in this paper: Szerlong, H. J., & Hansen, J. C. (2011). Nucleosome distribution and linker DNA: connecting nuclear function to dynamic chromatin structure. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire, 89(1), 24–34. doi:10.1139/O10-139

Improve this answer
$\endgroup$

You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .