There are a lot of publications, starting from 2000, about using telomerase for targeting cancer cells (it is upregulated in more than 80-90% of tumor cells). Specifically using its promoter (hTERT). In all publications, researches talking about the success of this approach. So my questions, why there is no use of this? What is the problem? I read a lot of articles - and didn't find an answer.
http://www.spandidos-publications.com/ijo/21/3/661 (one of the newest)