0
$\begingroup$

I'm interested in how dendritic cells present antigens to helper T-cells? I'm also interested in the molecular actions between a dendritic cell and a helper T-cell during the activation of the helper T-cell? What function does the homing receptor on a T-cell have?

$\endgroup$
  • $\begingroup$ what is your question? $\endgroup$ – AliceD Apr 2 '15 at 13:06
  • 2
    $\begingroup$ In the inflammatory response, dendritic cells mainly function as antigen-presenting cells, but the homing phenomenon happens under normal (non-inflammatory) conditions. Note that this is different from immune cell recruitment to the site of inflammation. You should specify under which context you'd like to know DC function. $\endgroup$ – Sleepses Apr 2 '15 at 14:23
  • 1
    $\begingroup$ @poka.nandor I must say the probability is high you are a good in-between lines reader :)... That edit... $\endgroup$ – cagliari2005 Apr 2 '15 at 15:13
  • 1
    $\begingroup$ @cagliari2005 - Thanks :) This seemed the most logical intention (at least for me) of the question based on title and the short description provided. $\endgroup$ – Nandor Poka Apr 2 '15 at 15:16
4
$\begingroup$

Dendritic cells are so called professional antigen-presenting cells (APCs) as pointed out by Sleepes in comment section. They express both MHC-I and MHC-II receptors on their cell surface on which they present small peptides. These small peptides come from digested proteins of their own (MHC-I) or antigens that were phagocited or taken up by receptor mediated endocytosis (MHC-II). They also express costimulatory molecules necessary for the activation of T-cells (eg. CD80/CD86).

T-cell activation source: http://journals.cambridge.org/fulltext_content/ERM/ERM2_09/S1462399400002143sup004.htm

As you can see in image above, activation of a T-cell requires two distinct signals: the recognition of an antigen and a co-stimulatory signal.

diversification of t-cells source: http://www.mhhe.com/biosci/ap/dynamichuman2/content/gifs/0158.gif

After activation T-cells undergo rapid division and diversification.

Details of T-cell activation by dendritic cells can be found in this article for example: Immunol Cell Biol. 1997 Jun;75(3):223-30. The role of dendritic cells in T cell activation. Ni K1, O'Neill HC.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.